Are there hypoallergenic cat breeds?
Quick answer
Not really — no cat breed is truly hypoallergenic, though some cats produce fewer of the proteins that trigger reactions, and for some allergy sufferers those cats are manageable.
The full answer
Cat allergies are usually caused by Fel d 1, a protein produced mainly in cats' saliva and skin glands and spread through dander, saliva, and urine. Because it is in saliva, it ends up on the coat when the cat grooms — so a hairless breed is not automatically safe. Breeds frequently described as lower-allergen include the Siberian, Balinese, Russian Blue, Devon Rex, Cornish Rex, Oriental Shorthair, and Sphynx. The evidence behind these claims is mixed and often anecdotal: research on Siberians, for example, has found that some individual cats produce much less Fel d 1 than others, but this varies far more from cat to cat than from breed to breed. Individual variation — and the fact that females and neutered cats often produce less than intact males — matters more than the breed label.
If you have cat allergies, test before you commit. Spend 30 to 60 minutes in a room with the specific cat you are considering, then see how you feel over the following hours. Many shelters allow meet-and-greets for exactly this reason.
If you already live with allergies, practical steps help more than breed choice: keep the bedroom cat-free, run a HEPA air purifier, replace carpet with hard flooring, wash bedding and cat beds weekly, and wash your hands after petting. A cat food containing anti-Fel d 1 antibodies (Purina Pro Plan LiveClear) has been shown to reduce active Fel d 1 on cat hair by up to 47%, and many allergy sufferers notice a real difference when it is combined with the steps above. Talk to your doctor about immunotherapy if symptoms are severe.